New research reveals that individuals who stop using blockbuster GLP-1 drugs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who halt traditional diet and exercise regimens.
Findings released in a prominent medical journal demonstrates that while overweight individuals often shed about a fifth of their body weight while using the jabs, the weight comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"People purchasing such treatments should be informed of the danger of fast rebound weight gain when the medication ends," cautioned expert Dr. Susan Jebb.
That rate of recovery implies a return to starting weight in about 18 months.
Weighing Therapies
The study, which looked at dozens of studies involving thousands of participants, compared the effects of the injectable medications with older methods.
The team emphasize that people who lose weight through diet and exercise generally experience a slower creep back—approximately 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Experts believe the way of the injections explains the accelerated weight return.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which moderates feelings of fullness.
"Artificially providing the hormone levels far above than normal may cause the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication results in appetite is no longer kept in check, making overeating far more likely."
An Ongoing Disease?
The NHS recommend the injections for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Many experts say that, considering the likelihood of weight regain, the treatment is often ongoing.
This opinion is reinforced by drug manufacturers, who say that the results "underscore the persistent character of excess weight," similar to managing diseases like high blood pressure.
User Testimonies
People who have come off the jabs describe a intense resurgence of appetite.
"It was like something flipping and you're instantly ravenous," said one woman.
This challenge is worsened if patients have not adopted permanent dietary or behavioural changes during therapy.
Widespread Adoption
Recent estimates indicate that millions of people in the UK have tried weight-loss jabs in the past year, with desire remaining high.
- Use is greater among women than men.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, clinicians caution that while the jabs are potent tools for weight loss, they are not a magic solution and lasting health benefits hinges on integrated lifestyle management.
